Progesterone
Progesterone is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing gender-affirming hormone therapy, it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims and no consensus. We recommend taking progesterone as a part of your regimen and have seen good results, especially when paired with other medications such as pioglitazone.
Dosage
Daily progesterone cap 200 mg two weeks on/two weeks off, taken as suppository (rectally). Do not start progesterone until you are Tanner 3.
Oral progesterone has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to boof it.[1] If you get it prescribed by a doctor, they'll probably give you oral progesterone. You need to take that capsule rectally (it's safe to do so), and you should cycle it. Common regimens are 100mg daily (uncycled); 200 mg two weeks on/two weeks off; or one week on, three weeks off. If taken too early, prog can inhibit breast development, so it is best to wait until Tanner 3 to start.
Medical establishment
The mainstream medical establishment does not recommend progesterone, citing lack of evidence and unknown risks (the usual excuses).[2] However, many medical systems do prescribe prog anyways, going against the guidelines.
References
- Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.
- Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.