Progesterone - Revision history

Afference at 01:06, 5 February 2026

2026-02-05T01:06:46Z

← Older revision		Revision as of 01:06, 5 February 2026
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	'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims~~. Oral progesterone also has bioavailability problems,~~ and in ~~order~~ to ~~derive~~ ~~any possible benefit from~~ progesterone, ~~you~~ ~~need~~ to ~~take~~ it ~~rectally~~ ~~(it~~ is an ~~oral~~ ~~medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on~~, ~~three~~ ~~weeks~~ ~~off.~~ ~~Progesterone~~ ~~should~~ ~~not~~ be ~~started until~~ [[~~Tanner~~]] ~~3 while on GAHT due to the fact that taking it too early can inhibit breast development~~.		'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims and no consensus. We recommend taking progesterone as a part of your regimen and have seen good results, especially when paired with other medications such as [[pioglitazone]].

			== Dosage ==

			Daily progesterone cap 200 mg two weeks on/two weeks off, taken as suppository (rectally). Do not start progesterone until you are [[Tanner]] 3.

			Oral progesterone has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to boof it.{{cite\|1}} If you get it prescribed by a doctor, they'll probably give you oral progesterone. You need to take that capsule rectally (it's safe to do so), and you should cycle it. Common regimens are 100mg daily (uncycled); 200 mg two weeks on/two weeks off; or one week on, three weeks off. If taken too early, prog can inhibit breast development, so it is best to wait until Tanner 3 to start.

	== Medical establishment ==		== Medical establishment ==
	The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual ~~escuses~~){{cite\|2}}. However, many medical systems do prescribe prog anyways, going against the guidelines.		The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual excuses).{{cite\|2}} However, many medical systems do prescribe prog anyways, going against the guidelines.

	== References ==		== References ==

Afference at 02:32, 2 February 2026

2026-02-02T02:32:58Z

← Older revision		Revision as of 02:32, 2 February 2026
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	'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until Tanner 3 while on GAHT due to the fact that taking it too early can inhibit breast development.		'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until [[Tanner]] 3 while on GAHT due to the fact that taking it too early can inhibit breast development.

	== Medical establishment ==		== Medical establishment ==

Afference at 02:32, 2 February 2026

2026-02-02T02:32:33Z

← Older revision		Revision as of 02:32, 2 February 2026
Line 1:		Line 1:
	'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until at ~~least~~ ~~one~~ ~~year of~~ GAHT, due to the fact that taking it too early can inhibit breast development.		'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until Tanner 3 while on GAHT due to the fact that taking it too early can inhibit breast development.

	== Medical establishment ==		== Medical establishment ==
	The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite\|2}}. However, many medical systems do prescribe prog anyways (going against the guidelines).		The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite\|2}}. However, many medical systems do prescribe prog anyways, going against the guidelines.

	== References ==		== References ==

Afference: Created page with "'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing gender-affirming hormone therapy, it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take..."

2026-02-02T02:27:30Z

Created page with "'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing gender-affirming hormone therapy, it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take..."

New page

'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until at least one year of GAHT, due to the fact that taking it too early can inhibit breast development.

== Medical establishment ==
The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite|2}}. However, many medical systems do prescribe prog anyways (going against the guidelines).

== References ==
<ol>
{{citation|1|Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.}}
{{citation|2|Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.}}
</ol>