glitterzone - User contributions [en]

Progesterone

2026-02-05T01:06:46Z

Afference:

'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims and no consensus. We recommend taking progesterone as a part of your regimen and have seen good results, especially when paired with other medications such as [[pioglitazone]].

== Dosage ==

Daily progesterone cap 200 mg two weeks on/two weeks off, taken as suppository (rectally). Do not start progesterone until you are [[Tanner]] 3.

Oral progesterone has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to boof it.{{cite|1}} If you get it prescribed by a doctor, they'll probably give you oral progesterone. You need to take that capsule rectally (it's safe to do so), and you should cycle it. Common regimens are 100mg daily (uncycled); 200 mg two weeks on/two weeks off; or one week on, three weeks off. If taken too early, prog can inhibit breast development, so it is best to wait until Tanner 3 to start.

== Medical establishment ==
The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual excuses).{{cite|2}} However, many medical systems do prescribe prog anyways, going against the guidelines.

== References ==
<ol>
{{citation|1|Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.}}
{{citation|2|Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.}}
</ol>

Gender-affirming hormone therapy

2026-02-05T00:58:17Z

Afference:

'''Gender-affirming hormone therapy''', colloquially called '''HRT''', is when you take hormones of the opposite sex in order to change your own sex. Some possible effects of feminizing HRT are:
* [[breast development]] (conetits)
* smooth skin
* crying
However, the most common effect is nothing. To actually make sure that you have a chance of seeing effects, you need to make sure that you aren't being [[hondose|hondosed]] and that you're cycling [[progesterone]]. You may also take [[pioglitazone]] and [[clobetasol]] and undergo [[cryolipolysis]] to speed up fat redistribution.

Gender-affirming hormone therapy

2026-02-05T00:57:57Z

Afference:

'''Gender-affirming hormone therapy''', colloquially called '''HRT''', is when you take hormones of the opposite sex in order to change your own sex. Some possible effects of feminizing HRT are:
* [[breast development]] (conetits)
* smooth skin
* crying
However, the most common effect is nothing. To actually make sure that you have a chance of seeing effects, you need to make sure that you aren't being [[hondosed]] and that you're cycling [[progesterone]]. You may also take [[pioglitazone]] and [[clobetasol]] and undergo [[cryolipolysis]] to speed up fat redistribution.

Gender-affirming hormone therapy

2026-02-05T00:56:18Z

Afference:

Main Page

2026-02-03T05:30:37Z

Afference: /* Rules */

Welcome to the '''Glitter Zone'''! Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]
* [[Clobetasol]]

== What is the Glitter Zone? ==
This is a place to document different treatments for transsex individuals. Unlike other wikis, we are not neutral. We believe that gender dysphoria is a medical issue, and we are willing to push the bounds of science in order to treat it. We hope to document unconventional and novel therapies and regimens for [[gender-affirming hormone therapy]], [[breast enhancement]], surgeries, and more. We are willing to call out obvious bullshit, [[hondose|hondosing]], and all of the other ways the existing [[medical establishment]] tries to fuck us over. We are pro-[[DIY HRT]] and believe that every person is endowed the right to bodily autonomy, meaning that they can decide for themselves if they want to take a drug and if the risks are acceptable.

While not neutral, articles should be scientific in nature, providing sources where available and noting what is speculative.

== Rules ==
* Do not post images of real people without their express permission. (Exception: public figures)
* Don't be a bitch.
* Don't do something stupid that makes me come up with new rules.

== How to edit ==
This is the same software as Wikipedia (MediaWiki), so it works the same way as Wikipedia. To protect ourselves from drive-by shitposters we require accounts to be approved by admins before being able to edit.

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/
* https://nbe.works/

Main Page

2026-02-03T05:18:04Z

Afference: /* Webring */

Welcome to the '''Glitter Zone'''! Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]
* [[Clobetasol]]

== What is the Glitter Zone? ==
This is a place to document different treatments for transsex individuals. Unlike other wikis, we are not neutral. We believe that gender dysphoria is a medical issue, and we are willing to push the bounds of science in order to treat it. We hope to document unconventional and novel therapies and regimens for [[gender-affirming hormone therapy]], [[breast enhancement]], surgeries, and more. We are willing to call out obvious bullshit, [[hondose|hondosing]], and all of the other ways the existing [[medical establishment]] tries to fuck us over. We are pro-[[DIY HRT]] and believe that every person is endowed the right to bodily autonomy, meaning that they can decide for themselves if they want to take a drug and if the risks are acceptable.

While not neutral, articles should be scientific in nature, providing sources where available and noting what is speculative.

== Rules ==
* Do not post images of real people without their express permission.
* Don't be a bitch.
* Don't do something stupid that makes me come up with new rules.

== How to edit ==
This is the same software as Wikipedia (MediaWiki), so it works the same way as Wikipedia. To protect ourselves from drive-by shitposters we require accounts to be approved by admins before being able to edit.

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/
* https://nbe.works/

Main Page

2026-02-02T03:27:20Z

Afference: /* What is the Glitter Zone? */

Welcome to the '''Glitter Zone'''! Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]
* [[Clobetasol]]

== What is the Glitter Zone? ==
This is a place to document different treatments for transsex individuals. Unlike other wikis, we are not neutral. We believe that gender dysphoria is a medical issue, and we are willing to push the bounds of science in order to treat it. We hope to document unconventional and novel therapies and regimens for [[gender-affirming hormone therapy]], [[breast enhancement]], surgeries, and more. We are willing to call out obvious bullshit, [[hondose|hondosing]], and all of the other ways the existing [[medical establishment]] tries to fuck us over. We are pro-[[DIY HRT]] and believe that every person is endowed the right to bodily autonomy, meaning that they can decide for themselves if they want to take a drug and if the risks are acceptable.

While not neutral, articles should be scientific in nature, providing sources where available and noting what is speculative.

== Rules ==
* Do not post images of real people without their express permission.
* Don't be a bitch.
* Don't do something stupid that makes me come up with new rules.

== How to edit ==
This is the same software as Wikipedia (MediaWiki), so it works the same way as Wikipedia. To protect ourselves from drive-by shitposters we require accounts to be approved by admins before being able to edit.

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/

Main Page

2026-02-02T03:26:36Z

Afference:

Welcome to the '''Glitter Zone'''! Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]
* [[Clobetasol]]

== What is the Glitter Zone? ==
This is a place to document different treatments for transsex individuals. Unlike other wikis, we are not neutral. We believe that gender dysphoria is a medical issue, and we are willing to push the bounds of science in order to treat it. We hope to document unconventional and novel therapies and regimens for [[gender-affirming hormone therapy]], [[breast enhancement]], surgeries, and more. We are willing to call out obvious bullshit, [[hondosing|hondose]], and all of the other ways the existing [[medical establishment]] tries to fuck us over. We are pro-[[DIY HRT]] and believe that every person is endowed the right to bodily autonomy, meaning that they can decide for themselves if they want to take a drug and if the risks are acceptable.

While not neutral, articles should be scientific in nature, providing sources where available and noting what is speculative.

== Rules ==
* Do not post images of real people without their express permission.
* Don't be a bitch.
* Don't do something stupid that makes me come up with new rules.

== How to edit ==
This is the same software as Wikipedia (MediaWiki), so it works the same way as Wikipedia. To protect ourselves from drive-by shitposters we require accounts to be approved by admins before being able to edit.

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/

Progesterone

2026-02-02T02:32:58Z

Afference:

'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until [[Tanner]] 3 while on GAHT due to the fact that taking it too early can inhibit breast development.

== Medical establishment ==
The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite|2}}. However, many medical systems do prescribe prog anyways, going against the guidelines.

== References ==
<ol>
{{citation|1|Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.}}
{{citation|2|Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.}}
</ol>

Progesterone

2026-02-02T02:32:33Z

Afference:

'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until Tanner 3 while on GAHT due to the fact that taking it too early can inhibit breast development.

== Medical establishment ==
The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite|2}}. However, many medical systems do prescribe prog anyways, going against the guidelines.

== References ==
<ol>
{{citation|1|Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.}}
{{citation|2|Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.}}
</ol>

DIY HRT

2026-02-02T02:29:35Z

Afference:

'''DIY HRT''' refers to taking [[HRT]] without a doctor's prescription. Due to systemic roadblocks created by the [[medical establishment]], DIY HRT is sometimes the only way for people to get the lifesaving care that they need. DIY HRT is also safer, as you have access to actually effective medications and don't have to worry about getting [[hondose|hondosed]]. You would be surprised about how little doctors actually care about you and about how little they know of [[HRT]].

Progesterone

2026-02-02T02:27:30Z

Afference: Created page with "'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing gender-affirming hormone therapy, it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take..."

'''Progesterone''' is a female sex hormone, responsible for managing parts of the menstrual cycle. In feminizing [[gender-affirming hormone therapy]], it has been claimed to help with breast size, sexual desire, and mood, but there is a lack of scientific evidence for these claims. Oral progesterone also has bioavailability problems, and in order to derive any possible benefit from progesterone, you need to take it rectally (it is an oral medication but it's fine to take rectally). Common regimens are 100mg daily; 200 mg two weeks on/two weeks off; or one week on, three weeks off. Progesterone should not be started until at least one year of GAHT, due to the fact that taking it too early can inhibit breast development.

== Medical establishment ==
The mainstream [[medical establishment]] does not recommend progesterone, citing lack of evidence and unknown risks (the usual escuses){{cite|2}}. However, many medical systems do prescribe prog anyways (going against the guidelines).

== References ==
<ol>
{{citation|1|Aly. “Oral Progesterone Achieves Very Low Levels of Progesterone and Has Only Weak Progestogenic Effects.” Transfeminine Science, 4 Aug. 2018, transfemscience.org/articles/oral-p4-low-levels/. Accessed 1 Feb. 2026.}}
{{citation|2|Coleman, E., et al. “Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.” International Journal of Transgender Health, vol. 23, no. S1, 19 Aug. 2022, pp. S1–S259, https://doi.org/10.1080/26895269.2022.2100644.}}
</ol>

Clobetasol

2026-02-02T02:00:43Z

Afference:

Your boobs have glucocorticoids (GCs) in them with unique response to stimulation. where most places shrink fat depots in response to GC stimulation, in boobs it causes rapid adipocyte hyperplasia. the current protocol is a week of one day on one day off application of clobetasol cream directly to boobs, followed by 7 weeks off. it seems to work better on [[pio]]. this is a very new and developing thing so theres not much info on it yet

== background ==

Glucocorticoids seem to produce substantial adipocyte hyperplasia in women. There are multiple accounts of cis women taking these medications developing macromastia and requiring surgical reduction of their breasts. In theory any GC will do, but because GCs have a number of undesireable effects including suppression of the HPA axis, immune system compromise, reduction of peripheral fat depots, promotion of visceral fat, and lots of other undesirable things, those of us who are trying them are mostly using topicals.

== directions ==

* due to aforementioned general GC use risks these medications are best cycled
* for full receptor reset you need around 6 weeks off
* unless youre underweight it seems safe to use this cream daily for a period of 2 weeks for your on cycle
* it seems to promote significant mammary fat increases in that time, particularly intramammary fat, like prog is known to do but much much faster
* growth is permanent, and effects are known to continue for up to after cessation due to buffering effect in skin and residual action
* they seem to be made significantly more effective when combined with at least 30mg pioglitazone a day
* skin thinning is possible with topicals, so it may be wise to use topical tretinoin on them in your off time
* reasonably large dose will be between 4 and 6g of cream total, which if topical to systemic numbers are to be trusted puts this at 1/10th the typical circulating levels for the lowest dose of oral corticosteroids

familliarise yourself with GC [https://www.ccjm.org/content/91/4/245 side effects] before using and do not attempt to use them while ill or over compromised skin, including ingrown hairs. it would also be wise to apply this using rubber gloves so none absorbs via your hands. clobetasol is cheap and easy to acquire from many of the sources that will sell you pioglitazone.

== In short ==
* glucocorticoids strongly promote preadipocyte differentiation specifically
* their expression in terms of adipogenesis is hormonally constrained, premenopausal conditions reduce abdominal fat tissue growth vs postmenopausal and male tissue conditions, presumably applicable systemically
* use of topical concentrates GCs where we want them, minimising systemic circulation and off target adipogenesis
* PPARy agonists cause full maturation of progenitor cells produced by glucocorticoids
* estrogen and progesterone drive lipid uptake of new adipocytes

== evidence ==
current evidence and working theory for glucocorticoid induced breast growth:
existing cases in medicine:
10.1097/MAJ.0b013e3182277a09
10.1016/j.ijscr.2019.04.042
Troccola A, Maruccia M, Dessy LA, Onesti MG. Cortisone-induced gigantomastia during chemotherapy. Giornale di Chirurgia. 2011;32(5):266-269
here we have 3 cases of people who experienced macromastia specifically associated with corticosteroid use. obviously this isnt evidence that its useful to us, but its reason enough to look into it.

hypothetical mechanism of action:
10.1038/labinvest.2010.170
investigates glucocorticoid effects on adipocytes, establishes that it upregulates KLF15, an important factor in adipogenesis. blocking of GR via antagonist also prevented differentiation of mesenchymal stem cells from differentiating into adipocytes and fibroblasts, meaning GR activity is required for creation of adipocytes.

10.1091/mbc.e08-04-0420
investigates glucocorticoids, specifically dexamethasone, for their specific role in adipose development. finds that glucocorticoids are required for a key stage in preadipocyte differentiation into adipose tissue that cannot be performed by other components of the standard adipocyte culturing cocktail.

10.1016/j.lfs.2020.118363
confirms that it drives PPARy expression in differentiating preadipocyte cells, implying use of PPARy agonists can drive complete differentiation here if used in conjunction.

10.3389/fendo.2022.889923
tells us that estrogen has a constraining effect on adipogenesis. estrogen facilitates adipocyte hyperplasia, and its absence both in postmenopausal and male hormonal conditions results in hypertrophy instead of hyperplasia in fat stores. ERa density is a key factor in this. PPARy agonists drive full maturation from now committed adipocyte progenitor cells.

== betamethasone ==
betamethasone may be preferable to clobetasol due to increased proportion of adipogenesis to fibrosis, but its a less tested option and we dont know how the valerate ester affects absorbtion into breast

Pio

2026-02-02T01:59:13Z

Afference: Redirected page to Pioglitazone

#REDIRECT [[pioglitazone]]

Clobetasol

2026-02-02T01:59:01Z

Afference:

Your boobs have glucocorticoids (GCs) in them with unique response to stimulation. where most places shrink fat depots in response to GC stimulation, in boobs it causes rapid adipocyte hyperplasia. the current protocol is a week of one day on one day off application of clobetasol cream directly to boobs, followed by 7 weeks off. it seems to work better on [[pio]]. this is a very new and developing thing so theres not much info on it yet

== background ==

Glucocorticoids seem to produce substantial adipocyte hyperplasia in women. There are multiple accounts of cis women taking these medications developing macromastia and requiring surgical reduction of their breasts. In theory any GC will do, but because GCs have a number of undesireable effects including suppression of the HPA axis, immune system compromise, reduction of peripheral fat depots, promotion of visceral fat, and lots of other undesirable things, those of us who are trying them are mostly using topicals. here is what we know about them so far:

* due to aforementioned general GC use risks these medications are best cycled
* for full receptor reset you need around 6 weeks off
* unless youre underweight it seems safe to use this cream daily for a period of 2 weeks for your on cycle
* it seems to promote significant mammary fat increases in that time, particularly intramammary fat, like prog is known to do but much much faster
* growth is permanent, and effects are known to continue for up to after cessation due to buffering effect in skin and residual action
* they seem to be made significantly more effective when combined with at least 30mg pioglitazone a day
* skin thinning is possible with topicals, so it may be wise to use topical tretinoin on them in your off time
* reasonably large dose will be between 4 and 6g of cream total, which if topical to systemic numbers are to be trusted puts this at 1/10th the typical circulating levels for the lowest dose of oral corticosteroids

familliarise yourself with GC side effects before using

https://www.ccjm.org/content/91/4/245

and do not attempt to use them while ill or over compromised skin, including ingrown hairs. it would also be wise to apply this using rubber gloves so none absorbs via your hands. clobetasol is cheap and easy to acquire from many of the sources that will sell you pioglitazone.

== In short ==
* glucocorticoids strongly promote preadipocyte differentiation specifically
* their expression in terms of adipogenesis is hormonally constrained, premenopausal conditions reduce abdominal fat tissue growth vs postmenopausal and male tissue conditions, presumably applicable systemically
* use of topical concentrates GCs where we want them, minimising systemic circulation and off target adipogenesis
* PPARy agonists cause full maturation of progenitor cells produced by glucocorticoids
* estrogen and progesterone drive lipid uptake of new adipocytes

== evidence ==
current evidence and working theory for glucocorticoid induced breast growth:
existing cases in medicine:
10.1097/MAJ.0b013e3182277a09
10.1016/j.ijscr.2019.04.042
Troccola A, Maruccia M, Dessy LA, Onesti MG. Cortisone-induced gigantomastia during chemotherapy. Giornale di Chirurgia. 2011;32(5):266-269
here we have 3 cases of people who experienced macromastia specifically associated with corticosteroid use. obviously this isnt evidence that its useful to us, but its reason enough to look into it.

hypothetical mechanism of action:
10.1038/labinvest.2010.170
investigates glucocorticoid effects on adipocytes, establishes that it upregulates KLF15, an important factor in adipogenesis. blocking of GR via antagonist also prevented differentiation of mesenchymal stem cells from differentiating into adipocytes and fibroblasts, meaning GR activity is required for creation of adipocytes.

10.1091/mbc.e08-04-0420
investigates glucocorticoids, specifically dexamethasone, for their specific role in adipose development. finds that glucocorticoids are required for a key stage in preadipocyte differentiation into adipose tissue that cannot be performed by other components of the standard adipocyte culturing cocktail.

10.1016/j.lfs.2020.118363
confirms that it drives PPARy expression in differentiating preadipocyte cells, implying use of PPARy agonists can drive complete differentiation here if used in conjunction.

10.3389/fendo.2022.889923
tells us that estrogen has a constraining effect on adipogenesis. estrogen facilitates adipocyte hyperplasia, and its absence both in postmenopausal and male hormonal conditions results in hypertrophy instead of hyperplasia in fat stores. ERa density is a key factor in this. PPARy agonists drive full maturation from now committed adipocyte progenitor cells.

== betamethasone ==
betamethasone may be preferable to clobetasol due to increased proportion of adipogenesis to fibrosis, but its a less tested option and we dont know how the valerate ester affects absorbtion into breast

Clobetasol

2026-02-02T01:58:07Z

Afference: Created page with "is your boobs have GCs in them with unique response to stimulation. where most places shrink fat depots in response to GC stimulation, in boobs it causes rapid adipocyte hyperplasia. the current protocol is a week of one day on one day off application of clobetasol cream directly to boobs, followed by 7 weeks off. it seems to work better on pio. this is a very new and developing thing so theres not much info on it yet == background == Glucocorticoids seem to produce su..."

is your boobs have GCs in them with unique response to stimulation. where most places shrink fat depots in response to GC stimulation, in boobs it causes rapid adipocyte hyperplasia. the current protocol is a week of one day on one day off application of clobetasol cream directly to boobs, followed by 7 weeks off. it seems to work better on pio. this is a very new and developing thing so theres not much info on it yet

== background ==

Glucocorticoids seem to produce substantial adipocyte hyperplasia in women. There are multiple accounts of cis women taking these medications developing macromastia and requiring surgical reduction of their breasts. In theory any GC will do, but because GCs have a number of undesireable effects including suppression of the HPA axis, immune system compromise, reduction of peripheral fat depots, promotion of visceral fat, and lots of other undesirable things, those of us who are trying them are mostly using topicals. here is what we know about them so far:

* due to aforementioned general GC use risks these medications are best cycled
* for full receptor reset you need around 6 weeks off
* unless youre underweight it seems safe to use this cream daily for a period of 2 weeks for your on cycle
* it seems to promote significant mammary fat increases in that time, particularly intramammary fat, like prog is known to do but much much faster
* growth is permanent, and effects are known to continue for up to after cessation due to buffering effect in skin and residual action
* they seem to be made significantly more effective when combined with at least 30mg pioglitazone a day
* skin thinning is possible with topicals, so it may be wise to use topical tretinoin on them in your off time
* reasonably large dose will be between 4 and 6g of cream total, which if topical to systemic numbers are to be trusted puts this at 1/10th the typical circulating levels for the lowest dose of oral corticosteroids

familliarise yourself with GC side effects before using

https://www.ccjm.org/content/91/4/245

and do not attempt to use them while ill or over compromised skin, including ingrown hairs. it would also be wise to apply this using rubber gloves so none absorbs via your hands. clobetasol is cheap and easy to acquire from many of the sources that will sell you pioglitazone.

== In short ==
* glucocorticoids strongly promote preadipocyte differentiation specifically
* their expression in terms of adipogenesis is hormonally constrained, premenopausal conditions reduce abdominal fat tissue growth vs postmenopausal and male tissue conditions, presumably applicable systemically
* use of topical concentrates GCs where we want them, minimising systemic circulation and off target adipogenesis
* PPARy agonists cause full maturation of progenitor cells produced by glucocorticoids
* estrogen and progesterone drive lipid uptake of new adipocytes

== evidence ==
current evidence and working theory for glucocorticoid induced breast growth:
existing cases in medicine:
10.1097/MAJ.0b013e3182277a09
10.1016/j.ijscr.2019.04.042
Troccola A, Maruccia M, Dessy LA, Onesti MG. Cortisone-induced gigantomastia during chemotherapy. Giornale di Chirurgia. 2011;32(5):266-269
here we have 3 cases of people who experienced macromastia specifically associated with corticosteroid use. obviously this isnt evidence that its useful to us, but its reason enough to look into it.

hypothetical mechanism of action:
10.1038/labinvest.2010.170
investigates glucocorticoid effects on adipocytes, establishes that it upregulates KLF15, an important factor in adipogenesis. blocking of GR via antagonist also prevented differentiation of mesenchymal stem cells from differentiating into adipocytes and fibroblasts, meaning GR activity is required for creation of adipocytes.

10.1091/mbc.e08-04-0420
investigates glucocorticoids, specifically dexamethasone, for their specific role in adipose development. finds that glucocorticoids are required for a key stage in preadipocyte differentiation into adipose tissue that cannot be performed by other components of the standard adipocyte culturing cocktail.

10.1016/j.lfs.2020.118363
confirms that it drives PPARy expression in differentiating preadipocyte cells, implying use of PPARy agonists can drive complete differentiation here if used in conjunction.

10.3389/fendo.2022.889923
tells us that estrogen has a constraining effect on adipogenesis. estrogen facilitates adipocyte hyperplasia, and its absence both in postmenopausal and male hormonal conditions results in hypertrophy instead of hyperplasia in fat stores. ERa density is a key factor in this. PPARy agonists drive full maturation from now committed adipocyte progenitor cells.

== betamethasone ==
betamethasone may be preferable to clobetasol due to increased proportion of adipogenesis to fibrosis, but its a less tested option and we dont know how the valerate ester affects absorbtion into breast

Main Page

2026-02-02T01:51:51Z

Afference:

Main Page

2026-02-02T01:48:19Z

Afference:

Welcome to the '''Glitter Zone'''! Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/

Main Page

2026-02-02T01:38:05Z

Afference:

This is the '''glitter zone''', a safe space from [[chaser|chasers]], [[tucute|tucutes]], the [[medical establishment]], and [[chud|chuds]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

== Webring ==
Here are some resources beyond this wiki that are helpful:
* https://papers.lgbt
* https://transfemscience.org
* https://diyhrt.wiki/

Boymoder

2026-02-02T01:29:05Z

Afference:

{| class="wikitable" style="float:right;"
| https://files.catbox.moe/2cz5rp.jpg
|-
| A boymoder removing her hoodie.
|}

'''Boymoders''' are transgender women who present male while taking feminizing [[HRT]], typically by wearing women's jeans and oversized hoodies. Their disguise often falls flat when they are forced to remove their hoodie, revealing their boymoder tits.

HRT

2026-02-02T01:03:16Z

Afference: Redirected page to Gender-affirming hormone therapy

#REDIRECT [[gender-affirming hormone therapy]]

Gender-affirming hormone therapy

2026-02-02T01:01:59Z

Afference: Created page with "'''Gender-affirming hormone therapy''', colloquially called '''HRT''', is when you take hormones of the opposite sex in order to change your own sex."

'''Gender-affirming hormone therapy''', colloquially called '''HRT''', is when you take hormones of the opposite sex in order to change your own sex.

Spironolactone

2026-02-02T01:00:52Z

Afference:

{| class="wikitable" style="float:right;"
| https://upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Spironolacton.svg/330px-Spironolacton.svg.png
|-
| Believe it or not, useless.
|}

'''Spironolactone''', or '''spiro''' for short, is a commonly prescribed [[antiandrogen]] that is no better than placebo{{cite|1}}. Spironolactone is, at best, able to suppress small amounts of [[testosterone]] in conjunction with [[estradiol]], as in levels typically found in [[cisgender women|natal females]]. However, it is completely ineffective at suppressing testosterone in the levels required for successful [[gender-affirming hormone therapy]]. A typical dose is 100mg daily and a typical [[hondose]] is 50mg daily. The [[medical establishment]] loves prescribing spiro because it is one of the most commonly prescribed medications and is known to be safe, despite there being much better antiandrogens available like [[bicalutamide]] or [[cyproterone acetate]].

== References ==
<ol>
{{citation|1|Aly. “A Review of Studies on Spironolactone and Testosterone Suppression in Cisgender Men, Cisgender Women, and Transfeminine People.” Transfeminine Science, 19 Dec. 2018, https://transfemscience.org/articles/spiro-testosterone/. Accessed 2 Feb. 2026.}}
</ol>

Medical establishment

2026-02-02T01:00:12Z

Afference: /* Harmful practices of institutional medicine */

The '''medical establishment''' is the machine of hospital systems, administrative overhead, government regulators, big pharma, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by [[hondose|hondosing]] you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, [[DIY HRT]] is much safer than trusting a doctor not to screw up the dosing on your medication, and it's also cheaper than going through insurance. Most doctors live in blind subservience to the establishment. A notable exception is [[Will Powers|Dr. Will Powers]], who has gained quite a big reputation for actually caring about his patients, even though he is a bit of a crackpot.

== Harmful practices of institutional medicine ==
* [[Hondose|Hondosing.]]
* Risk avoidance. They are more concerned about their own liability than your personal well-being.
* Stopping HRT during hospital stays. ''You should never interrupt your HRT. Interruptions can cause bone density issues.''
* Long waiting lists.
* Blocking minors from getting life-saving care, thus dooming them to a male puberty.

Spironolactone

2026-02-02T00:59:34Z

Afference: Created page with "{| class="wikitable" style="float:right;" | https://upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Spironolacton.svg/330px-Spironolacton.svg.png |- | Believe it or not, useless. |} '''Spironolactone''', or '''spiro''' for short, is a commonly prescribed antiandrogen that is no better than placebo{{cite|1}}. Spironolactone is, at best, able to suppress small amounts of testosterone in conjunction with estradiol, with the levels typically found in cisgend..."

{| class="wikitable" style="float:right;"
| https://upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Spironolacton.svg/330px-Spironolacton.svg.png
|-
| Believe it or not, useless.
|}

'''Spironolactone''', or '''spiro''' for short, is a commonly prescribed [[antiandrogen]] that is no better than placebo{{cite|1}}. Spironolactone is, at best, able to suppress small amounts of [[testosterone]] in conjunction with [[estradiol]], with the levels typically found in [[cisgender women|natal females]]. However, it is completely ineffective at suppressing testosterone in the levels required for successful [[gender-affirming hormone therapy]]. A typical dose is 100mg daily and a typical [[hondose]] is 50mg daily. The [[medical establishment]] loves prescribing spiro because it is one of the most commonly prescribed medications and is known to be safe, despite there being much better antiandrogens available like [[bicalutamide]] or [[cyproterone acetate]].

== References ==
<ol>
{{citation|1|Aly. “A Review of Studies on Spironolactone and Testosterone Suppression in Cisgender Men, Cisgender Women, and Transfeminine People.” Transfeminine Science, 19 Dec. 2018, https://transfemscience.org/articles/spiro-testosterone/. Accessed 2 Feb. 2026.}}
</ol>

Medical establishment

2026-02-02T00:48:48Z

Afference:

The '''medical establishment''' is the machine of hospital systems, administrative overhead, government regulators, big pharma, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by [[hondose|hondosing]] you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, [[DIY HRT]] is much safer than trusting a doctor not to screw up the dosing on your medication, and it's also cheaper than going through insurance. Most doctors live in blind subservience to the establishment. A notable exception is [[Will Powers|Dr. Will Powers]], who has gained quite a big reputation for actually caring about his patients, even though he is a bit of a crackpot.

== Harmful practices of institutional medicine ==
* [[Hondose|Hondosing.]]
* Stopping HRT during hospital stays. ''You should never interrupt your HRT. Interruptions can cause bone density issues.''
* Long waiting lists.
* Blocking minors from getting life-saving care, thus dooming them to a male puberty.

Main Page

2026-02-02T00:48:35Z

Afference:

Institutional medicine

2026-02-02T00:48:17Z

Afference: Afference moved page Institutional medicine to Medical establishment

#REDIRECT [[Medical establishment]]

Medical establishment

2026-02-02T00:48:17Z

Afference: Afference moved page Institutional medicine to Medical establishment

The '''medical establishment''' is the machine of hospital systems, administrative overhead, government regulators, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by [[hondose|hondosing]] you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, [[DIY HRT]] is much safer than trusting a doctor not to screw up the dosing on your medication, and it's also cheaper than going through insurance. Most doctors live in blind subservience to the establishment. A notable exception is [[Will Powers|Dr. Will Powers]], who has gained quite a big reputation for actually caring about his patients, even though he is a bit of a crackpot.

== Harmful practices of institutional medicine ==
* [[Hondose|Hondosing.]]
* Stopping HRT during hospital stays. ''You should never interrupt your HRT. Interruptions can cause bone density issues.''
* Long waiting lists.
* Blocking minors from getting life-saving care, thus dooming them to a male puberty.

Medical establishment

2026-02-02T00:48:01Z

Afference:

DIY HRT

2026-02-02T00:41:46Z

Afference: Created page with "'''DIY HRT''' refers to taking HRT without a doctor's prescription. Due to systemic roadblocks created by institutional medicine, DIY HRT is sometimes the only way for people to get the lifesaving care that they need. DIY HRT is also safer, as you have access to actually effective medications and don't have to worry about getting hondosed."

'''DIY HRT''' refers to taking [[HRT]] without a doctor's prescription. Due to systemic roadblocks created by [[institutional medicine]], DIY HRT is sometimes the only way for people to get the lifesaving care that they need. DIY HRT is also safer, as you have access to actually effective medications and don't have to worry about getting [[hondose|hondosed]].

Medical establishment

2026-02-02T00:38:46Z

Afference:

'''Institutional medicine''' is the machine of hospital systems, administrative overhead, government regulators, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by [[hondose|hondosing]] you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, [[DIY HRT]] is much safer than trusting a doctor not to screw up the dosing on your medication, and it's also cheaper than going through insurance. Most doctors live in blind subservience to institutional medicine. A notable exception is [[Will Powers|Dr. Will Powers]], who has gained quite a big reputation for actually caring about his patients, even though he is a bit of a crackpot.

== Harmful practices of institutional medicine ==
* [[Hondose|Hondosing.]]
* Stopping HRT during hospital stays. ''You should never interrupt your HRT. Interruptions can cause bone density issues.''
* Long waiting lists.
* Blocking minors from getting life-saving care, thus dooming them to a male puberty.

Medical establishment

2026-02-02T00:30:59Z

Afference:

'''Institutional medicine''' is the machine of hospital systems, administrative overhead, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by [[hondose|hondosing]] you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, [[DIY HRT]] is much safer than trusting a doctor not to screw up the dosing on your medication, and it's also cheaper than going through insurance. Most doctors live in blind subservience to institutional medicine. A notable exception is [[Will Powers|Dr. Will Powers]], who has gained quite a big reputation for actually caring about his patients, even though he is a bit of a crackpot.

Medical establishment

2026-02-02T00:28:47Z

Afference:

Medical establishment

2026-02-02T00:27:58Z

Afference: Created page with "'''Institutional medicine''' is the machine of hospital systems, administrative overhead, health insurance, pharmacists, doctors, and nurses that collectively conspire to screw you over by hondosing you. They have legislated themselves into existence in a form of [https://en.wikipedia.org/wiki/Rent-seeking rent-seeking] by trying to prevent you from getting your own drugs. Despite widespread propaganda to the contrary, DIY HRT is much safer than trusting..."

Main Page

2026-02-02T00:18:13Z

Afference:

This is the '''glitter zone''', a safe space from [[chaser|chasers]], [[tucute|tucutes]], [[institutional medicine]], and [[chud|chuds]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

Main Page

2026-02-02T00:17:00Z

Afference:

This is the '''glitter zone''', a safe space from [[chaser|chasers]], [[tucute|tucutes]], and [[chud|chuds]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

Main Page

2026-02-02T00:16:38Z

Afference:

This is the '''glitter zone''', a safe space from [[chasers|chaser]], [[tucutes|tucute]], and [[chuds|chud]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotestosterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

Main Page

2026-02-02T00:16:10Z

Afference:

This is the '''glitter zone''', a safe space from [[chasers|chaser]], [[tucutes|tucute]], and [[chuds|chud]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[Testosterone]]
* [[Estradiol]]
* [[Dihydrotesterone]]
* [[Progesterone]]

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

Main Page

2026-02-02T00:04:13Z

Afference:

This is the '''glitter zone''', a safe space from [[chasers|chaser]], [[tucutes|tucute]], and [[chuds|chud]] alike.

Learn about [[DIY HRT]] and the various sex hormones:
* [[T]] Testosterone
* [[E2]] Estradiol
* [[DHT]] Dihydrotesterone
* [[P4]] Progesterone

Or unconventional medications:
* [[Pioglitazone]]
* [[Domperidone]]

Boymoder

2026-02-01T23:57:52Z

Afference:

{| class="wikitable" style="float:right;"
| https://files.catbox.moe/2cz5rp.jpg
|-
| A boymoder removing her hoodie.
|}

'''Boymoders''' are transgender women who present male while taking feminizing [[hrt]], typically by wearing women's jeans and oversized hoodies. Their disguise often falls flat when they are forced to remove their hoodie, revealing their boymoder tits.

Boymoder

2026-02-01T23:17:20Z

Afference:

{| style="float:right; border:1px solid black; background: #ededed"
| https://files.catbox.moe/2cz5rp.jpg
|-
| A boymoder removing her hoodie.
|}

'''Boymoders''' are transgender women who present male while taking feminizing [[hrt]], typically by wearing women's jeans and oversized hoodies. Their disguise often falls flat when they are forced to remove their hoodie, revealing their boymoder tits.

Boymoder

2026-02-01T23:12:09Z

Afference:

'''Boymoders''' are transgender women who present male while taking feminizing [[hrt]], typically by wearing women's jeans and oversized hoodies. Their disguise often falls flat when they are forced to remove their hoodie, revealing their boymoder tits.

{| style="float:right; border:1px solid black;"
| https://files.catbox.moe/2cz5rp.jpg|100px
|-
| A boymoder removing her hoodie.
|}

Boymoder

2026-02-01T22:55:30Z

Afference: Created page with "'''Boymoders''' are transgender women who present male while taking feminizing hrt, typically by wearing women's jeans and oversized hoodies. Their disguise often falls flat when they are forced to remove their hoodie, revealing their boymoder tits."

/lgbt/

2026-02-01T22:52:05Z

Afference: Created page with "4chan's '''/lgbt/''' board, also known as '''/tttt/''' due to the fact that 95% of the posters on the board are transgender, is widely regarded as the cesspit of the online trans community. Despite once being much more respectable, it has been overrun by chasers and bait threads, and is responsible for the creation and sexualization of the boymoder character and some terrible ideas like DIY orchi. Still, it is one of the only places not overrun by babytrans,..."

4chan's '''/lgbt/''' board, also known as '''/tttt/''' due to the fact that 95% of the posters on the board are transgender, is widely regarded as the cesspit of the online trans community. Despite once being much more respectable, it has been overrun by chasers and bait threads, and is responsible for the creation and sexualization of the [[boymoder]] character and some terrible ideas like [[DIY orchi]]. Still, it is one of the only places not overrun by [[babytrans]], which makes it better than [[/r/mtf]].

Hon

2026-02-01T22:46:20Z

Afference: Created page with "'''Hons''' are trans women who do not pass. Their lives are very bleak, so you should treat them with respect and pity when you see one."

'''Hons''' are trans women who do not pass. Their lives are very bleak, so you should treat them with respect and pity when you see one.

Hondose

2026-02-01T22:44:53Z

Afference: Created page with "A '''hondose''' is a comically small dose of HRT prescribed by doctors to unsuspecting babytrans. Due to the fact the dose is inadequate, it won't cause much feminization, thus dooming the unfortunate recipient to forever be a hon. In any sane world this would be considered medical malpractice."

A '''hondose''' is a comically small dose of [[HRT]] prescribed by doctors to unsuspecting [[babytrans]]. Due to the fact the dose is inadequate, it won't cause much feminization, thus dooming the unfortunate recipient to forever be a [[hon]]. In any sane world this would be considered medical malpractice.

MediaWiki:Common.css

2026-02-01T22:35:49Z

Afference: Created page with "/* CSS placed here will be applied to all skins */ .mw-wiki-logo { background-size: contain }"

/* CSS placed here will be applied to all skins */
.mw-wiki-logo {
background-size: contain
}

User:Afference

2026-02-01T21:48:23Z

Afference: Created page with "Hello"

Hello